Collagen synthesis and remodeling are critical

on 27.8.08 with 0 comments

  • FGF, made by macrophages, stimulates fibroblasts

  • at confluence, fibroblasts stop dividing

  • fibroblasts secrete tropocollagen, a precursor of collagen

  • tropocollagen polymerizes outside the cells to form collagen

  • collagen polymers are dissolved by collagenases made by macrophages. this remodeling can proceed for a year, and the collagen fibers that do persist are aligned in the direction of most stress

  • so repetition of this process causes collagen fibers to line up along lines of stress

  • new collagen configuration attains about 80% strength of original and is never as flexible

  • protein deficiency delays the rate of collagen synthesis

  • vitamin C deficiency reduces the total strength of the scar

Category: Pathology Notes



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