Different modes of injury and healing

on 27.8.08 with 0 comments

  • acute injury progresses to acute inflammation

  • if not much tissue damage occurs, then the capillary bed doesn’t have to grow new capillaries, and resolution is rapid

  • if there is more extensive damage, a war between neutrophils and bacteria begins

    • the body builds a fibrous capsule around this war

    • you eventually develop a bag of pus, an abscess

    • neutrophils turn into soup and as a result the oncotic pressure inside the abscess increases

    • the abscess can burst, and indeed this is how they resolve themselves

    • then, assuming everything in there is dead, the body can reabsorb what used to be inside the abscess

  • injury causing chronic inflammation, often involving lymphocytes, leads not to abscess formation but to fibrosis

    • dense fibrosis is sometimes reabsorbed by macrophages or else remains as a disfiguring scar

    • then, regrowth of capillaries and venules occurs, a process termed revascularization

    • healing is accomplished by regeneration

Category: Pathology Notes



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