Global cerebral ischemia (from hypoperfusion of the entire brain)

on 30.1.09 with 0 comments

  • Selective vulnerability

    • Some neurons are more susceptible to ischemia (Purkinje cells are very vulnerable)

    • Not due to reduction of blood flow

    • Can see a ribbon-like area of necrosis since certain areas of the cerebral cortex are more vulnerable (called laminar infarcts)

  • Watershed infarcts

    • Infarcts at borders between arterial supply regions

    • These low perfusion areas are at higher risk of injury even with mild hypoxia

  • Respirator brain – autolytic softening of brain in veggies on respirators

Category: Pathology Notes



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