Progressive supranuclear palsy

on 28.1.09 with 0 comments

  • Initially, vertical gaze is lost (progresses to all eye movements); also see disequilibrium, rigidity, and dementia

  • Onset in later adulthood, males 2X more often, death within 10 years

  • Widespread atrophy in the deep gray matter (globus pallidus, subthalamic nucleus, tectum, preiaqueductal gray matter, and dentate nucleus) with sparing of the cortex and formation of tangles (not flame-shaped, but round [called “globos”]) that may contain small amounts of tau protein (not the major component like the tangles of AD

Category: Pathology Notes



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