Antibody therapy

on 17.3.09 with 1 comment



  • important for induction (at the time of allograft) as well as for acute rejection episodes

  • they are not chronically used for outpatient

  • “what does it sound like on the podcast when you swallow?”

  • antithymocyte globulin

    • mix of antibodies of many specificities

    • targets are CD2, 3, 4, 8, 11a, 25, 44, 45, etc.

    • used in induction/rejection

  • anti-CD3 monoclonal antibody

    • directed against epsilon chain of CD3; leads to receptor internalization and cell death/marginalization

    • therapy is limited because it is a mouse monoclonal antibody and humans mount an immune response against the drug

    • cytokine release syndrome leads to very sick patients (hypotension, pulmonary edema)

  • anti-IL-2-receptor antibodies (anti-CD25)

    • targets α chain of IL-2 receptor

    • used for induction as well as rejection


Category: Medical Subject Notes , Pathology Notes

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1 comments:

Abnova said...
March 18, 2009 at 8:22 AM

Thanks for share.

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