Compare and contrast features of intravascular and extravascular hemolysis.

on 4.3.09 with 0 comments

  • Intravascular

    • From normal RBCs being damaged by mechanical injury, complement fixation, or exogenous toxins

    • See anemia, jaundice, increased LDH, decreased serum haptoglobin (which binds up the toxic free Hb…decreased serum haptoglobin is pretty specific for anemia), hemoglobinemia, hemoglobinuria, and hemosiderinuria

    • Free Hb and metHb will be seen in serum and urine when haptoglobin is depleted

  • Extravascular

    • Occurs when RBCs are rendered “foreign” or become less deformable

    • RBC destruction occurs in the mononuclear phagocyte system (mostly spleen, some liver)

    • See anemia, jaundice, increased LDH, and normal to mildly decreased serum haptoglobin (since hemolysis is occurring outside of circulation, free Hb is not released in great amounts)

    • Hemoglobinemia or hemoglobinuria are absent or minimal

    • Splenomegaly may occur due to hypertrophy of the RES

Category: Medical Subject Notes , Pathology Notes



Post a Comment