Dysplastic maturational changes (megaloblastoid) of myelodysplastic syndromes

on 4.3.09 with 0 comments

  • Megaloblastoid changes in the absence of B12 or folate deficiency

  • These are macrocytic anemias that may or may not be seen with neutropenia, hypogranularity, thrombocytopenia, and/or monocytosis

  • The marrow is hypercellular and may have increased amounts of ringed sideroblasts

  • Many patients have chromosomal abnormalities and all are at an increased risk of infection and acute leukemia

  • This is a diagnosis of exclusion…always try to treat for B12 and/or folate deficiency first, and then move onto looking for this if there is no improvement

Category: Medical Subject Notes , Pathology Notes



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