Hematopoietic growth factors

on 7.3.09 with 0 comments

  • Stem cell factors (c-kit ligand, flt3-ligand) – stimulate production of pluripotent stem cells

  • EPO (erythropoietin)

    • Made by kidneys and liver

    • Stimulates erythropoiesis and megakaryocytopoiesis (problems with EPO will be manifested as RBC and platelet changes)

  • GM-CSF (granulocyte/monocyte colony stimulating factor)

    • Made by T cells and stimulated by fibroblasts, monocytes, and endothelial cells

    • Stimulates formation of granulocytes and monocytes from G/M-CFU

  • Interleukins

    • Hematopoietic cofactors from monocytes, lymphocytes, fibroblasts, and endothelial cells

    • IL-3 stimulates CFU-S (the myeloid stem cell)

    • IL-5 stimulates CFU-Eo (eosinophil stem cells)

  • Thrombopoietin – regulates megakaryocytopoiesis

Category: Medical Subject Notes , Pathology Notes



Post a Comment