Injury time scale

on 10.3.09 with 0 comments

  • when a cell is injured (alcohol, starvation, radiation, viral infection, autoimmunity), cell function (which can be measured biochemically) decreases rapidly

  • as function decreases, cell death or adaptation occurs

  • the rate of loss of ability to grow (i.e., the rate of death) occurs faster than any other changes

  • after a cell has died, you see ultrastructural changes (nuclear chromatin, lysosomes, polyribosomes)

  • then, you see light microscopic changes

  • so when a cell is dead, you won’t see any evidence with light microscopy until about six hours after death

  • gross morphologic changes occur only, say, after two days

Category: Medical Subject Notes , Pathology Notes



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