Wegener’s granulomatosis

on 17.3.09 with 0 comments

  • a necrotizing vasculitis

  • triad

    • necrotizing vasculitis of small- to medium-sized vessels, particularly in the lung

    • acute necrotizing granulomas of the upper respiratory tract

    • necrotizing glomerulonephritis

  • ding-dong: associated with c-ANCA, which is a sensitive and specific marker

  • males > females, 40-50 years old

Clinical features

  • pneumonitis

  • ulcers of the nasopharynx

  • renal disease

  • lots of different stuff


  • necrotizing vasculitis: vessel has been completely occluded and there is fibrinous necrosis of vessel wall

  • granulomatous inflammation—eosinophils, neutrophils

Clinical course

  • malignant disease: 80% of patients die within one year with no treatment

  • rx with steroids and immunosuppressants, inc. cyclophosphamide

Category: Medical Subject Notes , Pathology Notes



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