Pathological Calcification

on 12.10.05 with 0 comments

Metastatic Calcification
    • can occur anywhere in the body in tissue which do not normally mineralise when circulating levels of Ca2+ and PO43- are increased
    • can when tumours of parathyroid gland produce excess parathyroid hormone, or when excessive resorption of bone occurs (eg. tumour in bone)
Dystrophic calcification
    • occurs with normal levels of calcium and phosphate in tissues where nuclei allow mineral to precipitate
    • such nuclei occurs in degenerating or necrotic tissue
    • eg. atherosclerosis, infarcts, tumours, injured tissues
    • occurs within body cavities where degenerating or necrotic cells or micro-organisms provide nuclei for mineral deposition
    • eg. urinary tract (uroliathiasis), biliary tract (cholelithiasis) and salivary glands (sialolithiasis)
    • stone formation is not only facilitated by but also likely to lead to:
    • obstruction of flow
    • infection
    • inflammation and ulceration

Category: Pathology Notes



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