Chagas' Disease:Summary

on 10.12.08 with 0 comments

  • Trypanosoma cruzi, only in the New World

  • Transmission via bugs, blood transfusion and congenitally, rarely orally

  • Importance of poverty (housing)

  • Acute (especially children): chancre, RomaƱa’s sign, fever, lymphadenophathy, myocarditis, hepatosplenomegaly

  • Chronic: cardiac arrhythmias, heart failure, emboli, apical aneurysms

  • Chronic: dysphagia, constipation (mega-syndrome)

  • Diagnosis: clinical + thick smear/buffy coat (early), serology, xenodiagnosis, ECG, X-ray (late), PCR

  • Treatment in the early phase still reasonably successful with medication; in the late phase difficult

  • Benznidazole: problems with bone marrow toxicity, hypersensitivity, peripheral neuropathy.

  • Prevention: much progress in recent years via vector control and control of blood banks.

Category: Medicine Notes



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