HIV-Associated Nephropathy (HIVAN)

on 11.12.08 with 0 comments

  1. Know the characteristics of HIVAN at the level of light microscopy

    • Glomeruli

    • FSG w/ hyalinosis

    • Collapse of capillaries around mesangia

    • Swelling of epithelial cells w/ accumulation of hyaline droplets in cytoplasm

    • Dilation of capsular space containing cast-like material

  • Tubule

    • Dilation, flattening of epithelium, hyaline droplets, necrosis

    • Eosinophillic casts containing IgA, IgG, IgM, complement, albumin, kappa, and lambda, No Tamm-Horsfall protein. Scalloped appearance at periphery of casts

    • Interstitial nephritis

  1. Both HAN and HIVAN show focal segmental glomerulosclerosis. What are the differences between HAN and HIVAN clinically and at the level of electonmicroscopy?

    • Tubular reticular inclusions are commonly seen in endothelial cells

    • Cylindrical confronting cysternae in lymphocytes, macrophages, and endothelial cells

  2. Know the prevalence of HIVAN in different groups of patients

    • More frequent in blacks and drug abusers

Category: Pathology Notes



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