Forebrain anomalies

on 6.2.09 with 0 comments

  • Most are idiopathic

  • Polymicrogyria: disorganization of the cortex with many small, worm-looking gyri

  • Microcephaly (small head or small brain)

    • FAS most common cause

    • Also from congenital HIV and chromosomal abnormalities

  • Holoprosencephaly

    • There’s a single frontal lobe and a single lateral ventricle because of incomplete separation

    • Severe cases have facial deformities like cyclopia and a nose in the forehead (nose cannot descend to where it needs to be since that one big eye is in the way)

    • Mildest cases involve total lack of olfactory bulbs (arrhinencephaly)

    • Associated with trisomy 13

  • Agenesis of the corpus callosum can produce anything from a mentally retarded kid to a totally normal kid

Category: Pathology Notes



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