Neonatal/post-transfusional thrombocytopenia

on 9.2.09 with 0 comments

  • Mediated by Abs against a specific platelet Ag (e.g., Duzo, PL, Bak)

  • Neonatal

    • Mom exposed to a fetal platelet Ag she doesn’t have

    • IgG anti-fetal platelet Abs cross the placenta and destroy the fetus’ platelets

  • Post-transfusional

    • This is an anamnestic response to previous sensitization (maybe from transfusion, maybe from pregnancy) to certain platelet Ags that the patient doesn’t have

    • When given a transfusion, platelets that have said Ag will be coated with Ab and their survival will greatly decrease

Category: Medical Subject Notes , Pathology Notes



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