Some notes about clotting factor abnormalities

on 9.2.09 with 0 comments

  • All of these will show bleeding (not petechial bleeding as is seen with platelet defects, but as large ecchymoses or hematomas after a minor injury) with normal platelet number and function

  • The intrinsic pathway is measured by aPTT, the extrinsic by the PT; both measure the formation of fibrin (thus, problems with the common pathway will show prolongation of both PT and aPTT)

  • Factor XIII polymerizes fibrin, thus problems with factor XIII will show lots of bleeding, with normal platelet number and function, PT, aPTT, and thrombin time

  • Bleeding into GI and GU tracts and into weight-bearing joints is common

Category: Medical Subject Notes , Pathology Notes



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