Microangiopathic hemolytic anemias

on 4.3.09 with 0 comments

    • Hemolysis is from narrowing or obstructions in microvasculature

    • Will see things that look like bite cells as well as small fragments of RBCs

    • DIC

      • The presence of microthrombi in capillaries

      • Always secondary; may be seen with metastatic malignancies, sepsis, severe burns, etc

    • HUS

      • F, ARF, and thrombocytopenia

      • There is deposition of microthrombi in renal arterioles and glomerular capillaries due to endothelial damage

      • Can come from infection with enterics or S. pneumoniae in kids or with pregnancy, autoimmunity, or immune suppression in adults; it carries a better prognosis in kids

    • Thrombotic thrombocytopenic purpura (TTP)

      • Like HUS, but there’s also CNS C/S

      • Most common in young adults, and is seen more often in women

      • Used to be 90% fatal; early recognition and treatment with plasmapheresis has dropped the mortality

    • Malignant HTN (narrowing of arterioles)

    • Renal cortical necrosis

    • Necrotizing arteritis (SLE)

    • Kasabach-Merrit syndrome (from formation of microthrombi in a congenital giant cavernous hemangioma)

  • Cardiac traumatic hemolytic anemia (AKA macroangiopathic hemolysis)

    • Diseased or mechanical valves damage RBCs

    • The biggest problem was the ole ball in cage heart valve

Category: Medical Subject Notes , Pathology Notes



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