Risk-benefit ratio in immunosuppression

on 17.3.09 with 0 comments

  • nephrotoxicity is part of the risk-benefit ratio for calcineurin inhibitors

  • there is a long list of long-term risks of malignancies—cervical cell carcinoma; squamous cell carcinoma of the skin in both genders

  • availability of alternate therapies. dialysis is an option for patients with chronic renal failure, but there is no similar option for heart or liver transplant patients

  • clinical experience helps to guide decisions re intensification vs. taper of drug therapy

Other uses of these agents

  • autoimmune disease

    • drugs: cyclosporine, azathioprine, glucocorticoids

    • diseases: rheumatoid arthritis, multiple sclerosis, type 1 diabetes, autoimmune kidney diseases

  • inflammatory diseases

    • drugs: glucocorticoids

Category: Medical Subject Notes , Pathology Notes



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